COMPANY OVERVIEW
Entero Therapeutics is a clinical stage biopharmaceutical company specializing in the development of targeted, orally delivered therapies for gastrointestinal (GI) diseases.
Entero Therapeutics is currently advancing a therapeutic development pipeline populated with multiple clinical stage programs built around its three proprietary technologies – latiglutenase, a potentially first-in-class oral biotherapeutic designed to aid gluten digestion and potentially reduce symptoms of celiac disease; capeserod, a selective 5-HT4 receptor partial agonist being developed for multiple GI indications; and adrulipase, a recombinant lipase designed to enable the digestion of fats and other nutrients in patients with exocrine pancreatic insufficiency.
OUR TEAM
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JAMES SAPIRSTEIN - CHAIRMAN & CHIEF EXECUTIVE OFFICER |
Mr. Sapirstein has served for over thirty-nine years in the pharmaceutical industry. After spending seventeen years in large Pharma companies, Mr. Sapirstein started his career in smaller biotech companies when he later joined Gilead Sciences, Inc. to lead the Global Marketing team in its launch of Viread (tenofovir). In 2002, he accepted the position of Executive Vice President, Metabolic and Endocrinology, for Serono Laboratories. Later, in 2006, he became the founding Chief Executive Officer of Tobira Therapeutics, then a private company. Tobira Therapeutics was acquired by Allergan in 2016. In 2012, Mr. Sapirstein became the Chief Executive Officer of Alliqua, Inc. Thereafter, he served as Chief Executive Officer of Contravir Pharmaceuticals from March 2014 until October 2018. Mr. Sapirstein has raised over $400 Million dollars in venture capital and public capital markets financing in his various engagements as Chief Executive Officer. He was named as a Finalist for the Ernst & Young Entrepreneur of the Year award in 2015 as well as in 2016. Mr. Sapirstein currently holds board positions on Renovaro Biosciences, ZyVersa Therapeutics and Onconetix Inc. He was Chairman of the Board for BioNJ, an association of biopharma industries in New Jersey from February 2017 to February 2019. In addition, he is a member of the Board of Directors for BIO (Biotechnology Innovation Organization), the leading biotechnology trade organization promoting public policy and networking in the healthcare space, where he sits on the Emerging Companies Section Governing Board and Health Section Board. Mr. Sapirstein received a BS (Pharmacy) from Rutgers University and an MBA from Fairleigh Dickinson University. |
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SARAH ROMANO - CHIEF FINANCIAL OFFICER |
Sarah Romano, CPA, was appointed as Chief Financial Officer of Entero Therapeutics (formerly First Wave BioPharma) in March 2022. She previously served as Chief Financial Officer of Kiora Pharmaceuticals, Inc. (NASDAQ: KPRX) (formerly EyeGate Pharmaceuticals, Inc.), a clinical-stage specialty pharmaceutical company developing products for treating ophthalmic diseases, from February 2017 through February 2022 and as its Corporate Controller from August 2016 to January 2017. Prior to joining Kiora, Ms. Romano served as Assistant Controller at TechTarget from June 2015 through August 2016 and Corporate Controller at Bowdoin Group, a healthcare-focused executive recruiting firm, from September 2013 through May 2015. Previously, she held financial reporting positions of increasing responsibility at SoundBite Communications from 2008 until its acquisition by Genesys in 2013, and at Cognex Corporation from 2004 through 2008. |
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MARTIN KRUSIN - SVP FOR CORPORATE DEVELOPMENT |
Mr. Krusin is an experienced executive with 20 years of business development, strategic marketing, financing and operating experience in the healthcare, financial services, and consulting sectors. Prior to joining Entero Therapeutics (formerly First Wave BioPharma) as VP for Business Development in 2014, Mr. Krusin was VP for BD at FluoroPharma Medical, Inc.; Director of Business Development at Clewed (a business services and investment partnership); an Experienced Commercial Leader at GE Capital in its Global Sponsor Finance, Healthcare Financial Services, and Capital Solutions units; Vice President of Marketing & Sales and Director of Business Development at Electro-Optical Sciences (MelaSciences); and an analyst in the Emerging Markets Strategic Planning Group at Citigroup. |
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JENNIFER SEALEY-VOYKSNER, PH.D. - SVP FOR RESEARCH & DEVELOPMENT |
Dr. Sealey-Voyksner has more than 30 years’ experience in academic and commercial research and development in pharmaceutical, environmental and food sciences. Her expertise is the study and analysis of protein biomarkers and allergenic proteins. |
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TED STOVER - VP OF PRODUCT DEVELOPMENT |
Mr. Stover joined Entero Therapeutics (formerly First Wave BioPharma) in 2020 as the Product Development Director to oversee CMC and Project Management. Prior to joining Entero Therapeutics, Mr. Stover spent 20 years focused on manufacturing operations and analytical method development to support all stages of pharmaceutical drug development. Most recently Mr. Stover served as the Senior Director of Program Management for Biorasi after holding positions of Vice President Manufacturing at SCI and Operations Manager for Prioria Robotics. Mr. Stover earned his MBA from the University of Florida. |
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AMY CHANDLER - VP OF REGULATORY AFFAIRS, QA & COMPLIANCE |
Ms. Chandler has more than 25 years of experience in the medical device, pharmaceutical and combination product industries, supporting CNS, cardiovascular, endovascular, consumer and wound care product development and manufacturing. She began her career at Johnson & Johnson where she held multiple positions of increasing levels of responsibilities within the Quality Assurance organization (QAU, QA, QC, QE, SQA). She has expertise in the development of Quality Assurance and Regulatory Affairs organizations and systems throughout all stages of a product life cycle. In addition, she has created both US and international strategies and submissions to secure key regulatory approvals and ensure quality and compliance. Ms. Chandler holds a B.S. degree in Chemistry, a M.S. degree in Textile Technology, and is RAC (Global) certified. |
BOARD OF DIRECTORS
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JAMES SAPIRSTEIN - CHAIRMAN & CHIEF EXECUTIVE OFFICER |
Mr. Sapirstein has served for over thirty-nine years in the pharmaceutical industry. After spending seventeen years in large Pharma companies, Mr. Sapirstein started his career in smaller biotech companies when he later joined Gilead Sciences, Inc. to lead the Global Marketing team in its launch of Viread (tenofovir). In 2002, he accepted the position of Executive Vice President, Metabolic and Endocrinology, for Serono Laboratories. Later, in 2006, he became the founding Chief Executive Officer of Tobira Therapeutics, then a private company. Tobira Therapeutics was acquired by Allergan in 2016. In 2012, Mr. Sapirstein became the Chief Executive Officer of Alliqua, Inc. Thereafter, he served as Chief Executive Officer of Contravir Pharmaceuticals from March 2014 until October 2018. Mr. Sapirstein has raised over $400 Million dollars in venture capital and public capital markets financing in his various engagements as Chief Executive Officer. He was named as a Finalist for the Ernst & Young Entrepreneur of the Year award in 2015 as well as in 2016. Mr. Sapirstein currently holds board positions on Renovaro Biosciences, ZyVersa Therapeutics and Onconetix Inc. He was Chairman of the Board for BioNJ, an association of biopharma industries in New Jersey from February 2017 to February 2019. In addition, he is a member of the Board of Directors for BIO (Biotechnology Innovation Organization), the leading biotechnology trade organization promoting public policy and networking in the healthcare space, where he sits on the Emerging Companies Section Governing Board and Health Section Board. Mr. Sapirstein received a BS (Pharmacy) from Rutgers University and an MBA from Fairleigh Dickinson University. |
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EDWARD J. BORKOWSKI - LEAD INDEPENDENT DIRECTOR |
Mr. Borkowski joined our board of directors in May 2015. He previously served as the Executive Vice President at TherapeuticsMD and Chief Financial Officer of ConvaTec Healthcare, CareFusion Corporation and Mylan, Inc. and in a variety of finance positions at Pharmacia, American Home Products, Cyanamid and at Arthur Andersen. Mr. Borkowski holds a Bachelor of Science in Economics and Political Science from Allegheny College and a Master in Business Administration in Finance and Accounting from Rutgers University. |
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TIMOTHY RAMDEEN - DIRECTOR |
Timothy R. Ramdeen has nearly a decade of experience in private equity and hedge fund investing, capital markets, and company formation. Since June 2022, Mr. Ramdeen has been founder and managing partner of Dharma Capital Advisors, an investment and advisory firm focused on early-stage private and public companies. From March 2021 to March 2022, Mr. Ramdeen was co-founder, chief investment officer, and portfolio manager at Sixth Borough Capital Management, a multi-stage, event-driven hedge fund focused on both private and public equities. Since 2022, Mr. Ramdeen has been the co-founder of Amplexd Therapeutics, which is a women’s health/biotechnology company focused on providing low-cost, effective, safe and accessible treatments for early cervical and HPV-related cancers worldwide. Mr. Ramdeen also serves as a corporate advisor/board member to multiple early-stage companies and investment funds. Previously, Mr. Ramdeen was the fifth hire at Altium Capital Management (“Altium”), a healthcare-focused investment firm, where from July 2019 to March 2021 he served as the sole investment analyst on the private capital markets/special situations desk (privately-negotiated financings, direct investments, event-driven long/short, and private to public investments in micro and small-cap companies). During his tenure at Altium, Mr. Ramdeen was instrumental in co-creating the firm’s SPAC and reverse merger investment efforts and establishing extensive relationships with sell-side constituents, buy-side counterparts, and hundreds of private and publicly traded companies across biotechnology, therapeutics, healthcare services, medical devices and medtech. Prior to Altium, from September 2017 to July 2019, Mr. Ramdeen served as the sole investment analyst at Brio Capital Management, a New York-based event-driven/special situations hedge fund focused on small-cap equities, where he invested as a generalist. In addition to spearheading all investments on behalf of the firm, Mr. Ramdeen assumed increasing degrees of responsibility and oversight including general fund/business operations, investor relations, capital raising/business development and compliance. Before entering public markets investing, Prior to 2017, Mr. Ramdeen also spent time in private equity working for both a private New York‑based family office and Focus Financial Partners, a publicly traded holding company. Mr. Ramdeen received his B.S. in Biology from Temple University, where he conducted scientific research across neurology, oncology, and developmental biology. In addition, Mr. Ramdeen earned his MBA in Finance from NYU Stern School of Business. |
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ALASTAIR RIDDELL MSc. MBChB. DSc. - DIRECTOR |
Dr. Riddell joined our board of directors in September 2015. He is also currently Chairman of a private UK biotech, Nemesis Biosciences Ltd, Chairman of a UK AIM listed medical imaging company Feedback plc and Chairman of the South West Academic Health Science Network, which fosters links between the NHS, industry and universities. He was also on the board of directors of another US private company, Skyline Vet Pharma until April 2017. Dr. Riddell has over 30 years experience in the pharmaceutical, life science and biotech industries, 18 years as main board director. After 10 years directing phases 1-4 clinical trials of antibiotics, oncology and intensive care products for companies including Lederle (now Pfizer) and Centocor (now J&J), he spent 5 years managing sales and marketing for oncology and imaging products for Amersham International (now GE Healthcare). This led to 12 years as CEO for 3 UK biotech companies, Pharmagene, Paradigm Therapeutics and Stem Cell Sciences; in these roles he was the principal involved in significant fund raising including an IPO on UK’s main list and trade sales to Takeda in Japan and Stem Cells Inc. in the USA. He has since had several roles in UK government initiatives related to promoting cooperation between pharmaceutical companies and the NHS and assessing projects for funding with Innovate UK. He began his career as a medical doctor in a variety of hospital specialties and in general practice. He was recently awarded a Doctorate of Science, Honoris Causa by Aston University. |
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JACK SYAGE, PH.D. – DIRECTOR |
Dr. Syage has over 30 years of experience in creating and leading the development of innovative technologies in medical and analytical instrumentation. He is regarded as a leading expert in mass spectrometry and trace chemical detection. |